Randomised trial of iodine intake and thyroid status

Background—Low levels of circulating thyroid hormones have been associated with poorer general and neurodevelopmental outcome in preterm babies and it has been speculated that the association is causal. Low levels of circulating thyroid hormone have been reported after inadequate intake of iodine in preterm infants being fed milk formula. Aim—To investigate whether increased iodine intake from supplemented preterm formula would improve thyroid hormone levels in preterm babies (this study) and hence improve neurodevelopmental status (planned subsequent study). Method—A total of 121 preterm infants were entered into a randomised controlled trial of standard (68 μg/l) versus increased (272 μg/l) iodine in preterm formula. Results—The two groups were comparable at recruitment. No evidence of an eVect of the intervention on thyroid hormone levels was seen up to 41 weeks after conception. Conclusion—Calls for increased iodine content of preterm infant formulas are not justified by this study. (Arch Dis Child Fetal Neonatal Ed 2000;83:F86–F90)